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Supplement
NAD+ Injection
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NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme involved in energy metabolism, DNA repair, and cell signaling. Levels tend to decline with age and certain stressors. While wellness clinics use NAD+ infusions or injections, robust human outcome data for injections remain limited; most human evidence shows that oral precursors can raise NAD+ levels, not that injections improve specific clinical endpoints.
Check eligibilityNAD+ injections are not FDA-approved to diagnose, treat, cure, or prevent any disease, or for performance, anti-aging, or energy enhancement.
Why it works
Key benefits
- May improve perceived energy or stamina in some individuals
- Possible support for recovery and cellular repair pathways
- May aid focus and mental clarity in some users
- Investigated for healthy aging and metabolic health
Early/limited evidence. These potential effects are hypothesis-generating and vary by person; strong injection-specific outcome data are limited.
Mechanism
How it works
NAD+ supports mitochondrial ATP production and activates repair enzymes (sirtuins, PARPs). In humans, studies show that precursors like nicotinamide riboside (NR) can increase blood or brain NAD+; whether injections produce superior outcomes versus oral precursors is not established.
Frequently asked questions
FAQs
Any changes in energy or mood are usually subtle and gradual. Perceived effects, if any, differ by individual, dose, and rate of administration.
Common and usually transient: flushing or warmth, redness at the site, headache, nausea, or lightheadedness (more likely with rapid administration). Rare fatigue post-infusion has been reported.
Before you begin
Informed Consent & Safety
Important: FDA has received adverse event reports consistent with endotoxin contamination from some compounded NAD+ injectables; use reputable sources and report persistent or severe reactions promptly.
Research & Studies
Evidence at a Glance
- 1.
Covarrubias AJ et al. Nat Rev Mol Cell Biol (2021). NAD+ metabolism and aging.
- 2.
Dellinger RW et al. Sci Rep (2017). NR increases whole-blood NAD+ in humans.
- 3.
Nanga RPR et al. Magn Reson Med (2024). Acute NR increases brain NAD+.
- 4.
Poljšak B et al. Nutrients (2022). Challenges for NAD+ boosters.
Interested in NAD+ Injection?
Take a short assessment and a licensed provider will review if this treatment is right for you.
Clinical Guidance Disclaimer
The information provided in this document is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. It should never replace sound clinical judgment or personalized advice of a qualified healthcare professional. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or treatment protocol. Never disregard professional medical advice or delay in seeking it because of something you have read in these materials.
Liability & Indemnification
By utilizing this information, the user acknowledges and agrees that REBL and its affiliates, providers, and staff are not liable for any direct, indirect, or consequential damages resulting from the use or misuse of the information provided herein. Any reliance on the materials contained in this document is solely at the user's own risk.
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