Actual medication label and appearance may vary
Peptide Treatment
MOTS-c Injection
Choose a treatment option
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a synthetic peptide derived from the mitochondrial genome. Known as a "mitochondrial-derived peptide," it plays a critical role in cellular metabolism, energy regulation, and exercise mimesis.
Check eligibilityMOTS-c is being studied for its potential to support metabolic health and physical performance, though rigorous human clinical data remain limited. MOTS-c is not FDA-approved to diagnose, treat, cure, or prevent any disease or illness.
Why it works
Key benefits
- Metabolic Support: Enhances glucose metabolism and supports healthy insulin sensitivity.
- Physical Performance: May improve exercise capacity, stamina, and physical endurance.
- Weight Management: Possible assistance with fat metabolism and body composition.
- Cellular Health: Investigated for its role in supporting mitochondrial function and healthy aging.
Based on early and preclinical data
Mechanism
How it works
MOTS-c acts primarily on metabolic pathways to promote cellular homeostasis. Preclinical studies suggest it enhances insulin sensitivity, promotes glucose uptake into skeletal muscle, and stimulates fatty acid oxidation. By mimicking some of the metabolic effects of exercise at the cellular level, it helps the body manage energy and metabolic stress more efficiently.
Frequently asked questions
FAQs
Perceived improvements in energy levels or exercise recovery, when they occur, are typically gradual and may begin to appear after 2–4 weeks of consistent use. Optimal metabolic changes and shifts in body composition generally require 6–12 weeks of continued therapy. Results vary significantly based on individual metabolism, diet, and activity levels.
Most individuals tolerate MOTS-c therapy well. Potential effects may include: Temporary redness, swelling, or irritation at the injection site. Mild headache or transient fatigue. Rare lightheadedness or nausea.
Before you begin
Informed Consent & Safety
Report any persistent or severe symptoms to your provider immediately.
Research & Studies
Evidence at a Glance
- 1.
Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin-Montalvo, A., Wan, J., Kim, S. J., Mehta, H., Hevener, A. L., de Cabo, R., & Cohen, P. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454.
- 2.
Kim, S. J., Miller, B., Kumagai, H., Yen, K., & Cohen, P. (2018). MOTS-c: An update on its role in metabolic homeostasis and aging. Free Radical Biology and Medicine, 127, 178–181.
- 3.
Kim, S. J., Miller, B., Zada, D., Kumagai, H., Wan, J., Omura, S., Yen, K., & Cohen, P. (2021). Mitochondrial-derived peptide MOTS-c is an exercise-induced DNA-binding hormone that enters the nucleus and regulates metabolic stress. Nature Communications, 12(1), 1–15.
- 4.
Reynolds, J. C., Lai, R. W., Woodhead, J. S. T., Joly, J. H., Mitchell, C. J., Koehnke, D., Cohen, P., & Merry, T. L. (2021). MOTS-c is an exercise-induced mitochondrial-derived peptide that attenuates insulin resistance and aging-related physical decline. Journal of Clinical Investigation, 131(4).
Interested in MOTS-c Injection?
Take a short assessment and a licensed provider will review if this treatment is right for you.
Clinical Guidance Disclaimer
The information provided in this document is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. It should never replace sound clinical judgment or personalized advice of a qualified healthcare professional. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or treatment protocol. Never disregard professional medical advice or delay in seeking it because of something you have read in these materials.
Liability & Indemnification
By utilizing this information, the user acknowledges and agrees that REBL and its affiliates, providers, and staff are not liable for any direct, indirect, or consequential damages resulting from the use or misuse of the information provided herein. Any reliance on the materials contained in this document is solely at the user's own risk.
Proprietary Rights & Use Restrictions
This document and its contents are the proprietary property of REBL. Unauthorized use, duplication, reproduction, or distribution of these materials—in whole or in part—without express written consent is strictly prohibited.