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Peptide Treatment
GHK-Cu (Copper Peptide)
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GHK-Cu (glycyl-L-histidyl-L-lysine–copper) is a naturally occurring copper-binding peptide found in human plasma and saliva. It is widely studied in dermatology and wound care for its potential to support collagen/elastin synthesis, dermal remodeling, and antioxidant/anti-inflammatory activity. Most robust human data are topical; systemic use is more limited and investigational.
Check eligibilityGHK-Cu is not FDA-approved to diagnose, treat, cure, or prevent any disease or medical illness.
Why it works
Key benefits
- Support for wound healing and post-procedure recovery (primarily topical data)
- Improved skin texture, firmness, and elasticity (cosmetic studies)
- Antioxidant and anti-inflammatory support that may complement tissue repair
Mechanism
How it works
GHK-Cu can modulate gene expression linked to tissue repair, increase dermal fibroblast activity, and support angiogenesis and nerve outgrowth in preclinical models. In small clinical studies and cosmetic trials, topical GHK-Cu improved skin texture, fine lines, firmness, and wound healing metrics.
Frequently asked questions
FAQs
Topical use: gradual changes in texture/firmness over 4–8 weeks. Procedural or injected use aims at focal remodeling; outcomes vary with technique and aftercare.
Generally well tolerated topically. Potential irritation, erythema, itching, or sensitivity at application/injection sites.
Before you begin
Informed Consent & Safety
Rare allergic reactions are possible; discontinue and notify your clinician if persistent.
Research & Studies
Evidence at a Glance
- 1.
Pickart L, Margolina A. Int J Mol Sci (2018). Regenerative and protective actions of GHK-Cu; gene-expression and human cosmetic data summarized.
- 2.
Pickart L. Int J Mol Sci (2017). GHK effects on gene programs relevant to tissue and nervous system support.
- 3.
Clinical and cosmetic studies cited within Pickart 2018 review report improvements in skin appearance after GHK-Cu creams/serums..
Interested in GHK-Cu (Copper Peptide)?
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Clinical Guidance Disclaimer
The information provided in this document is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. It should never replace sound clinical judgment or personalized advice of a qualified healthcare professional. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or treatment protocol. Never disregard professional medical advice or delay in seeking it because of something you have read in these materials.
Liability & Indemnification
By utilizing this information, the user acknowledges and agrees that REBL and its affiliates, providers, and staff are not liable for any direct, indirect, or consequential damages resulting from the use or misuse of the information provided herein. Any reliance on the materials contained in this document is solely at the user's own risk.
Regulatory Status
Cosmetic/topical products containing GHK-Cu are sold OTC; injectable preparations are compounded and not FDA-approved for aesthetic/dermatologic indications.
Proprietary Rights & Use Restrictions
This document and its contents are the proprietary property of REBL. Unauthorized use, duplication, reproduction, or distribution of these materials—in whole or in part—without express written consent is strictly prohibited.